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This study investigates the immune-related causes of neurological symptoms that appear after COVID-19 (neuro-PASC, long COVID) in veterans. It enrolls people who had a SARS-CoV-2 infection at least 4 weeks earlier, with one group made up of those experiencing new neurological symptoms after infection. This non-phase observational study is currently recruiting.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: Eligible participants will: * have a history of SARS-CoV-2 infection 4 weeks prior to enrollment, defined as a positive PCR or home antigen test * be able to give informed consent as determined by brief cognitive exam and evaluation of understanding of the risks, benefits, and voluntary nature of the study Additionally, participants enrolled as part of the neuro-PASC group must also: * currently experience neuro-PASC symptoms, not present prior to infection, as confirmed by the "Long COVID-19 Symptom Assessment" scale, a self-report measure that consists of 46 common COVID-19 sequela symptoms Exclusion Criteria: Exclusion criteria for all groups: * diagnosed with dementia, traumatic brain injury, a neurological syndrome (e.g. Parkinson disease, Alzheimer disease), or other progressive cognitive disorder before SARS-CoV-2 infection * diagnosed with a mood or psychotic disorder before SARS-CoV-2 infection * history of fibromyalgia or chronic fatigue syndrome prior to SARS-CoV-2 infection * unstable medical conditions or active uncontrolled autoimmune or inflammatory conditions