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This study examines how genetic polymorphisms and the DASH diet affect the weight-loss process in menopausal women with metabolic syndrome. It enrolls women aged 40-60 who are obese and have a diagnosis of metabolic syndrome. This non-phase study is currently recruiting.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * The study population will consist of menopausal women aged between 40 to 60 years old * Obese (BMI \> 30) with a diagnosis of MS. The inclusion criteria are the presence of at least 3 of the 5 criteria\* for MS, which include: * Abnormal waist circumference values (≥89 cm in women) * SBP ≥120 mm Hg and DBP ≥80 mm Hg) or diagnosis of hypertension * Fasting blood glucose equal to or greater than 100 mg/dL or diagnosis of DM2 * HDL-c less than 50 mg/dL in women * Triglycerides ≥150 mg/dL. Exclusion Criteria: * Patients with a BMI \<25 kg/m2 The following chronic diseases will not be eligible: * Active cancer * Active tuberculosis * Psychiatric illnesses * Multiple sclerosis * Severe nephropathy * Advanced stages of Paget's disease. These chronic conditions could interfere with the results of this study, especially adherence to diet and weight loss. Patients who do not complete all stages of the study, who are not adhering to the intervention or who present any complication that interferes with the results of the study will be excluded from the study.