Mechanisms and Targeted Therapy of Airway Basal Cell Dysfunction in Bronchiolitis Obliterans Syndrome

Plain-language summary

This study investigates the mechanisms behind airway basal cell dysfunction and possible targeted treatments in patients with bronchiolitis obliterans syndrome (a lung disease involving narrowing of the small airways). It includes patients who have undergone allogeneic hematopoietic stem cell transplantation and been diagnosed with this syndrome. It is a study without an assigned phase and enrolls participants by invitation.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Enrolling by invitation

Sponsor

Haikou Affiliated Hospital of Central South University Xiangya School of Medicine

Intervention

Bronchoscopic brushing, Single - cell cloning, Cell function identification, Identification of local microenvironmental changes, Gene editing, Prevention of ferret airway basal cell transplantation, Transplantation treatment of ferret airway basal cells

Start date

1/1/2026

Estimated completion

6/30/2028

Countries

China

Related genes

Locations

• Haikou, China

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Patients who have received allogeneic hematopoietic stem cell transplantation and are diagnosed with bronchiolitis obliterans syndrome

Exclusion Criteria:

* Bronchoscopy consultation is not suitable for patients who are not suitable for bronchoscopy.