Fertility Preservation in Children With Solid Tumors: Detection of Residual Disease by a Sensitive Method

Plain-language summary

This study examines the detection of residual tumor cells using sensitive RT-qPCR and ddPCR methods in reproductive tissues stored for fertility preservation. Women undergoing laparoscopy for a benign cyst, men with non-obstructive azoospermia, and prepubertal children diagnosed with neuroblastoma or Ewing sarcoma may take part. This is a study without a clinical phase and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Recruiting

Sponsor

University Hospital, Clermont-Ferrand

Intervention

RT-qPCR, ddPCR

Start date

2/1/2025

Estimated completion

12/31/2027

Countries

France

Related genes

Locations

• Clermont-Ferrand, France

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Women of any age diagnosed with a benign cyst requiring laparoscopy may be included.
* Men of any age diagnosed with a non-obstructive azoospermia may be included.
* Prepubertal girls and boys diagnosed with neuroblastoma or Ewing sarcoma during infancy may be included.
* Capable of providing written informed consent to participate in the research study
* Affiliated with a social welfare service.
* For prepubertal patients, written informed consent to participate in the research study must be provided by their parents or legal guardians.

Exclusion Criteria:

* None