PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)

Plain-language summary

This study examines a personalized approach that includes sleep and dietary counseling, a supervised exercise program, and various supplements such as whey protein, creatine, Urolithin A, and Nicotinamide Mononucleotide (NMN) to support healthy aging. Adults aged 50-80 who are relatively healthy, have not exercised regularly in the past 12 months, and meet certain eligibility criteria can take part. It is a study with no assigned phase and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Recruiting

Sponsor

National University of Singapore

Intervention

Sleep and dietary counseling, Supervised exercise and exergaming program, Motivational interviewing, Whey protein, Creatine Monohydrate, Fucoidan, Urolithin A, Nicotinamide Mononucleotide (NMN), Multivitamin, Ergothioneine

Start date

9/29/2025

Estimated completion

6/30/2026

Countries

Singapore

Related genes

Locations

• Singapore, Singapore

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Age 50-80 years (both male and female)
* Relatively healthy and in stable health condition
* Not engaged in regular resistance or aerobic training in the past 12 months (i.e., untrained)
* VO₂peak below the 75th percentile for age- and sex-specific norms
* Cognitive performance below 75th percentile on the NIH Toolbox Cognitive Function Battery
* Willing and able to comply with exercise and supplementation protocols
* English-literate (can read and understand English)
* Provides written informed consent
* Deemed to have mental capacity, as assessed by the Principal Investigator
* Are able to attend all research visits for screening and research data collection at MD11, Yong Loo Lin School of Medicine, National University of Singapore

Exclusion Criteria:

* Significant change in medication in the past 3 months
* History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke)
* More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD)
* Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients
* Participation in another interventional clinical trial
* Current use of any study-related supplement unless willing to stop
* Any medical, psychiatric, or cognitive condition deemed by the PI to jeopardise safety or compliance
* Pregnant or planning pregnancy during the study period
* Any conditions deemed by PI that jeopardize the safety or study compliance