A Multi-omic Approach to the Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease (CMT1A)

Plain-language summary

This is an observational study examining a multi-omic approach to identify new biomarkers in individuals with early-stage Charcot-Marie-Tooth 1A disease (CMT1A). People aged 10-30 with a genetic diagnosis of CMT1A (or a clinical diagnosis with a genetic diagnosis in affected relatives) who can walk with or without support can take part. It is a study with no assigned phase and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Recruiting

Sponsor

University Medical Center Goettingen

Start date

3/24/2025

Estimated completion

9/30/2026

Countries

Germany

Related genes

Locations

• Göttingen, Germany

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion criteria:

* collaborative children, adolescents and young adults aged 10-30 years
* genetic diagnosis of CMT1A, or clinical diagnosis and genetic diagnosis in affected relatives
* able to walk with/ without support.

Exclusion Criteria:

* neuromuscular disorders other than CMT1A
* concomitant disease preventing correct patient evaluation and contraindication to qMRI