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AIRE

—Autoimmune Regulator

Chromosome: 21

Location: 21:44285838-44298648

OMIM: 607358

Ensembl: ENSG00000160224

Official·OMIM:607358 Official·ENSG00000160224

Encodes autoimmune regulator protein. Mutations cause APS type 1 (APECED).

Treatment Roadmap — AIRE

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

APECED (APS Type 1)

Autosomal RecessivePrevalence: 1/100000immunologic

Official·OMIM:240300 Official·ORPHA3453

Summary

Clinical Trial

Approved Therapy

Registered Variant