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APP

—Amyloid Beta Precursor Protein

Chromosome: 21

Location: 21:25880535-26171128

OMIM: 104760

Ensembl: ENSG00000142192

Official·OMIM:104760 Official·ENSG00000142192

Encodes amyloid beta precursor protein. Mutations cause early-onset Alzheimer disease.

Treatment Roadmap — APP

Preclinical

Phase 1

7 trial

Phase 2

12 trial

Phase 3

8 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Early-Onset Alzheimer Disease

Autosomal DominantPrevalence: 1/10000neurological

Official·OMIM:104300 Official·ORPHA1020

Summary

112

Clinical Trial

Approved Therapy

Registered Variant