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BRAF

—B-Raf Proto-Oncogene

Chromosome: 7

Location: 7:140719327-140925199

OMIM: 164757

Ensembl: ENSG00000157764

Official·OMIM:164757 Official·ENSG00000157764

Encodes serine/threonine kinase. V600E mutation is common in melanoma and colorectal cancer.

Treatment Roadmap — BRAF

Preclinical

Phase 1

17 trial

Phase 2

61 trial

Phase 3

8 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Melanoma (BRAF-mutant)

somaticPrevalence: ~150Koncologic

Official·OMIM:155600

Summary

153

Clinical Trial

Approved Therapy

Registered Variant