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CDK4

—Cyclin Dependent Kinase 4

Chromosome: 12

Location: 12:57746043-57756013

OMIM: 123829

Ensembl: ENSG00000135446

Official·OMIM:123829 Official·ENSG00000135446

Encodes cell cycle kinase. Mutations can cause familial melanoma.

Treatment Roadmap — CDK4

Preclinical

Phase 1

5 trial

Phase 2

24 trial

Phase 3

4 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Familial Melanoma

Autosomal DominantPrevalence: 1/10000oncologic

Official·OMIM:155600 Official·ORPHA618

Summary

Clinical Trial

Approved Therapy

Registered Variant