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CHEK2

—Checkpoint Kinase 2

Chromosome: 22

Location: 22:28687738-28742422

OMIM: 604373

Ensembl: ENSG00000183765

Official·OMIM:604373 Official·ENSG00000183765

Encodes cell cycle checkpoint kinase. Mutations predispose to breast cancer.

Treatment Roadmap — CHEK2

Preclinical

Phase 1

2 trial

Phase 2

15 trial

Phase 3

1 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Hereditary Breast-Ovarian Cancer Syndrome

Autosomal DominantPrevalence: 1/500oncologic

Official·OMIM:604370 Official·ORPHA145

Summary

Clinical Trial

Approved Therapy

Registered Variant