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DGUOK

—Deoxyguanosine Kinase

Chromosome: 2

Location: 2:73926794-73958961

OMIM: 601465

Ensembl: ENSG00000114956

Official·OMIM:601465 Official·ENSG00000114956

Encodes deoxyguanosine kinase. Mutations cause hepatocerebral mtDNA depletion syndrome.

Treatment Roadmap — DGUOK

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

mtDNA Depletion Syndrome (Hepatocerebral)

Autosomal RecessivePrevalence: 1/200000mitochondrial

Official·OMIM:251880 Official·ORPHA254902

Summary

Clinical Trial

Approved Therapy

Registered Variant