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ELANE

—Elastase Neutrophil Expressed

Chromosome: 19

Location: 19:850951-856247

OMIM: 130130

Ensembl: ENSG00000197561

Official·OMIM:130130 Official·ENSG00000197561

Encodes neutrophil elastase. Mutations cause cyclic and severe congenital neutropenia.

Treatment Roadmap — ELANE

Preclinical

Phase 1

1 trial

Phase 2

1 trial

Phase 3

1 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Severe Congenital Neutropenia

Autosomal DominantPrevalence: 1/200000hematologic

Official·OMIM:202700 Official·ORPHA486

Summary

Clinical Trial

Approved Therapy

Registered Variant