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FBN1

—Fibrillin 1

Chromosome: 15

Location: 15:48408016-48645791

OMIM: 134797

Ensembl: ENSG00000166147

Official·OMIM:134797 Official·ENSG00000166147

Encodes extracellular matrix protein fibrillin-1. Mutations cause Marfan syndrome.

Treatment Roadmap — FBN1

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Marfan Syndrome

Autosomal DominantPrevalence: ~200Kconnective_tissue

Official·OMIM:154700 Official·ORPHA558

Summary

Clinical Trial

Approved Therapy

Registered Variant