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FLG

—Filaggrin

Chromosome: 1

Location: 1:152302165-152325239

OMIM: 135940

Ensembl: ENSG00000143631

Official·OMIM:135940 Official·ENSG00000143631

Encodes filaggrin protein. Loss-of-function mutations predispose to ichthyosis vulgaris and atopic dermatitis.

Treatment Roadmap — FLG

Preclinical

Phase 1

Phase 2

4 trial

Phase 3

1 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Ichthyosis Vulgaris

Autosomal DominantPrevalence: 1/250dermatologic

Official·OMIM:146700 Official·ORPHA312

Summary

Clinical Trial

Approved Therapy

Registered Variant