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GRN

—Granulin Precursor

Chromosome: 17

Location: 17:44345108-44353106

OMIM: 138945

Ensembl: ENSG00000030582

Official·OMIM:138945 Official·ENSG00000030582

Encodes progranulin protein. Mutations cause frontotemporal dementia.

Treatment Roadmap — GRN

Preclinical

Phase 1

1 trial

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Frontotemporal Dementia

Autosomal DominantPrevalence: 1/10000neurological

Official·OMIM:600274 Official·ORPHA282

Summary

Clinical Trial

Approved Therapy

Registered Variant