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GUSB

—Glucuronidase Beta

Chromosome: 7

Location: 7:65960677-65982704

OMIM: 611499

Ensembl: ENSG00000169919

Official·OMIM:611499 Official·ENSG00000169919

Encodes beta-glucuronidase enzyme. Mutations cause MPS VII (Sly syndrome).

Treatment Roadmap — GUSB

Preclinical

Phase 1

1 trial

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Sly Syndrome

Autosomal RecessivePrevalence: 1/1000000lysosomal

Official·OMIM:253220 Official·ORPHA584

Summary

Clinical Trial

Approved Therapy

Registered Variant