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JAG1

—Jagged Canonical Notch Ligand 1

Chromosome: 20

Location: 20:10637684-10674396

OMIM: 601920

Ensembl: ENSG00000101384

Official·OMIM:601920 Official·ENSG00000101384

Encodes Notch signaling pathway ligand. Mutations cause Alagille syndrome.

Treatment Roadmap — JAG1

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Alagille Syndrome

Autosomal DominantPrevalence: 1/70000hepatic

Official·OMIM:118450 Official·ORPHA52

Summary

Clinical Trial

Approved Therapy

Registered Variant