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JAK3

—Janus Kinase 3

Chromosome: 19

Location: 19:17824780-17848071

OMIM: 600173

Ensembl: ENSG00000105639

Official·OMIM:600173 Official·ENSG00000105639

Encodes Janus kinase 3. Mutations cause autosomal recessive SCID.

Treatment Roadmap — JAK3

Preclinical

Phase 1

2 trial

Phase 2

1 trial

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

X-linked Severe Combined Immunodeficiency

Autosomal RecessivePrevalence: 1/100000immunologic

Official·OMIM:300400 Official·ORPHA276

Summary

Clinical Trial

Approved Therapy

Registered Variant