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LMNA

—Lamin A/C

Chromosome: 1

Location: 1:156082572-156140085

OMIM: 150330

Ensembl: ENSG00000160789

Official·OMIM:150330 Official·ENSG00000160789

Encodes nuclear lamin A/C protein. Mutations cause dilated CMP, EDMD, and progeria.

Treatment Roadmap — LMNA

Preclinical

Phase 1

Phase 2

2 trial

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Hutchinson-Gilford Progeria

Autosomal DominantPrevalence: 1/8000000connective_tissue

Official·OMIM:176670 Official·ORPHA740

Dilated Cardiomyopathy (LMNA-related)

Autosomal DominantPrevalence: 1/5000cardiac

Official·

LMNA

Treatment Roadmap — LMNA

Associated Diseases

Summary