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MLH1

—MutL Homolog 1

Chromosome: 3

Location: 3:36992834-37051505

OMIM: 120436

Ensembl: ENSG00000076242

Official·OMIM:120436 Official·ENSG00000076242

Encodes DNA mismatch repair protein. Mutations cause Lynch syndrome.

Treatment Roadmap — MLH1

Preclinical

Phase 1

1 trial

Phase 2

4 trial

Phase 3

1 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Lynch Syndrome

Autosomal DominantPrevalence: 1/440oncologic

Official·OMIM:120435 Official·ORPHA144

Summary

Clinical Trial

Approved Therapy

Registered Variant