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OTOF

—Otoferlin

Chromosome: 2

Location: 2:26457203-26558756

OMIM: 603681

Ensembl: ENSG00000115155

Official·OMIM:603681 Official·ENSG00000115155

Plays a role in synaptic vesicle fusion in inner ear hair cells. Mutations cause DFNB9 hearing loss.

Treatment Roadmap — OTOF

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Hereditary Hearing Loss (DFNB9)

Autosomal RecessivePrevalence: ~2Motologic

Official·OMIM:601071 Official·ORPHA90636

Summary

Clinical Trial

Approved Therapy

Registered Variant