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PKP2

—Plakophilin 2

Chromosome: 12

Location: 12:32790745-32896819

OMIM: 602861

Ensembl: ENSG00000057294

Official·OMIM:602861 Official·ENSG00000057294

Encodes desmosomal protein. Mutations cause arrhythmogenic right ventricular cardiomyopathy.

Treatment Roadmap — PKP2

Preclinical

Phase 1

2 trial

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Arrhythmogenic Cardiomyopathy

Autosomal DominantPrevalence: 1/5000cardiac

Official·OMIM:107970 Official·ORPHA247

Summary

Clinical Trial

Approved Therapy

Registered Variant