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POLG

—DNA Polymerase Gamma Catalytic Subunit

Chromosome: 15

Location: 15:89305198-89334972

OMIM: 174763

Ensembl: ENSG00000140521

Official·OMIM:174763 Official·ENSG00000140521

Encodes mitochondrial DNA polymerase gamma. Mutations cause Alpers syndrome and PEO.

Treatment Roadmap — POLG

Preclinical

Phase 1

Phase 2

1 trial

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Progressive External Ophthalmoplegia

Autosomal DominantPrevalence: 1/100000mitochondrial

Official·OMIM:157640 Official·ORPHA254892

Alpers Syndrome

Autosomal RecessivePrevalence: 1/200000mitochondrial

Official·

POLG

Treatment Roadmap — POLG

Associated Diseases

Summary