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PRKN

—Parkin RBR E3 Ubiquitin Protein Ligase

Chromosome: 6

Location: 6:161347417-162727775

OMIM: 602544

Ensembl: ENSG00000185345

Official·OMIM:602544 Official·ENSG00000185345

Encodes parkin ubiquitin ligase. Mutations cause early-onset Parkinson disease.

Treatment Roadmap — PRKN

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Early-Onset Parkinson Disease

Autosomal RecessivePrevalence: 1/10000neurological

Official·OMIM:600116 Official·ORPHA2828

Summary

Clinical Trial

Approved Therapy

Registered Variant