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PSEN1

—Presenilin 1

Chromosome: 14

Location: 14:73136418-73223691

OMIM: 104311

Ensembl: ENSG00000080815

Official·OMIM:104311 Official·ENSG00000080815

Encodes presenilin 1 protein. Mutations cause early-onset familial Alzheimer disease.

Treatment Roadmap — PSEN1

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Early-Onset Alzheimer Disease

Autosomal DominantPrevalence: 1/10000neurological

Official·OMIM:104300 Official·ORPHA1020

Summary

Clinical Trial

Approved Therapy

Registered Variant