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RAG2

—Recombination Activating 2

Chromosome: 11

Location: 11:36575574-36598279

OMIM: 179616

Ensembl: ENSG00000175097

Official·OMIM:179616 Official·ENSG00000175097

Encodes V(D)J recombinase enzyme. Mutations cause SCID and Omenn syndrome.

Treatment Roadmap — RAG2

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Omenn Syndrome

Autosomal RecessivePrevalence: 1/500000immunologic

Official·OMIM:603554 Official·ORPHA39041

Summary

Clinical Trial

Approved Therapy

Registered Variant