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RET

—Ret Proto-Oncogene

Chromosome: 10

Location: 10:43077026-43130351

OMIM: 164761

Ensembl: ENSG00000165731

Official·OMIM:164761 Official·ENSG00000165731

Encodes receptor tyrosine kinase. Mutations cause MEN2 and medullary thyroid cancer.

Treatment Roadmap — RET

Preclinical

Phase 1

5 trial

Phase 2

23 trial

Phase 3

1 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Multiple Endocrine Neoplasia Type 2

Autosomal DominantPrevalence: 1/30000oncologic

Official·OMIM:171400 Official·ORPHA653

Summary

Clinical Trial

Approved Therapy

Registered Variant