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SERPINA1

—Serpin Family A Member 1

Chromosome: 14

Location: 14:94376745-94391024

OMIM: 107400

Ensembl: ENSG00000197249

Official·OMIM:107400 Official·ENSG00000197249

Encodes alpha-1 antitrypsin protein. Mutations cause alpha-1 antitrypsin deficiency.

Treatment Roadmap — SERPINA1

Preclinical

Phase 1

2 trial

Phase 2

1 trial

Phase 3

1 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Alpha-1 Antitrypsin Deficiency

Autosomal RecessivePrevalence: 1/2500respiratory

Official·OMIM:613490 Official·ORPHA60

Summary

Clinical Trial

Approved Therapy

Registered Variant