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SMAD4

—SMAD Family Member 4

Chromosome: 18

Location: 18:51028528-51085045

OMIM: 600993

Ensembl: ENSG00000141646

Official·OMIM:600993 Official·ENSG00000141646

Encodes TGF-beta signaling pathway protein. Mutations cause juvenile polyposis syndrome.

Treatment Roadmap — SMAD4

Preclinical

Phase 1

Phase 2

1 trial

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Juvenile Polyposis Syndrome

Autosomal DominantPrevalence: 1/100000oncologic

Official·OMIM:174900 Official·ORPHA2929

Summary

Clinical Trial

Approved Therapy

Registered Variant