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TK2

—Thymidine Kinase 2

Chromosome: 16

Location: 16:66508003-66552544

OMIM: 188250

Ensembl: ENSG00000166548

Official·OMIM:188250 Official·ENSG00000166548

Encodes mitochondrial thymidine kinase 2. Mutations cause myopathic mtDNA depletion syndrome.

Treatment Roadmap — TK2

Preclinical

Phase 1

Phase 2

Phase 3

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

mtDNA Depletion Syndrome (Myopathic)

Autosomal RecessivePrevalence: 1/200000mitochondrial

Official·OMIM:609560 Official·ORPHA254875

Summary

Clinical Trial

Approved Therapy

Registered Variant