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UBE3A

—Ubiquitin Protein Ligase E3A

Chromosome: 15

Location: 15:25333728-25439092

OMIM: 601623

Ensembl: ENSG00000114062

Official·OMIM:601623 Official·ENSG00000114062

Encodes ubiquitin ligase E3A. Loss of maternal allele causes Angelman syndrome.

Treatment Roadmap — UBE3A

Preclinical

Phase 1

Phase 2

Phase 3

1 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Angelman Syndrome

maternal_imprintingPrevalence: 1/15000neurological

Official·OMIM:105830 Official·ORPHA72

Summary

Clinical Trial

Approved Therapy

Registered Variant