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UGT1A1

—UDP Glucuronosyltransferase Family 1 Member A1

Chromosome: 2

Location: 2:233760262-233773313

OMIM: 191740

Ensembl: ENSG00000241635

Official·OMIM:191740 Official·ENSG00000241635

Encodes bilirubin UDP-glucuronosyltransferase. Mutations cause Gilbert and Crigler-Najjar syndrome.

Treatment Roadmap — UGT1A1

Preclinical

Phase 1

13 trial

Phase 2

8 trial

Phase 3

1 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Crigler-Najjar Syndrome

Autosomal RecessivePrevalence: 1/1000000hepatic

Official·OMIM:218800 Official·ORPHA205

Summary

Clinical Trial

Approved Therapy

Registered Variant