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VHL

—Von Hippel-Lindau Tumor Suppressor

Chromosome: 3

Location: 3:10141778-10153676

OMIM: 608537

Ensembl: ENSG00000134086

Official·OMIM:608537 Official·ENSG00000134086

Encodes tumor suppressor VHL protein. Mutations cause VHL syndrome.

Treatment Roadmap — VHL

Preclinical

Phase 1

1 trial

Phase 2

6 trial

Phase 3

1 trial

Approved

Clinical trials have approximately 10% success rate. This roadmap shows the current status, not guaranteed outcomes.

Associated Diseases

Von Hippel-Lindau Syndrome

Autosomal DominantPrevalence: 1/36000oncologic

Official·OMIM:193300 Official·ORPHA892

Summary

Clinical Trial

Approved Therapy

Registered Variant