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This study examined dynamic contrast-enhanced magnetic resonance imaging (MRI) to assess the blood vessels associated with tumors in patients with metastatic breast cancer that had spread to the brain. Women aged 18 and over whose breast cancer had spread to the brain and who were scheduled for surgery could take part. It was carried out as a study with no assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: 1. A woman with a known or with radiographic evidence of a breast neoplasm metastatic to the brain, who has agreed to participate in the protocol "Analysis of Brain Metastasis in Patients with Breast Cancer, with and without over-expression of HER-2," and who will undergo a pre-operative MR scan immediately before surgery. 2. Medically-indicated (diagnostic and/or therapeutic) brain tumor resection. 3. Informed consent from female patient, age 18 or older. In general, patients less than 18 years of age rarely have breast cancer metastatic to the brain. Exclusion Criteria: 1. Inability to provide informed consent prior to surgery. 2. Medical conditions that cannot be corrected prior to surgery that would be standard contraindications for craniotomy (brain tumor patients). 3. Conditions that preclude MR imaging of the brain (Patients with pacemakers, cerebral aneurysm clips, shrapnel injury or implantable electronic devices) or known allergy to gadolinium. 4. Men