Analysis of Brain Metastasis in Patients With Breast Cancer, With and Without Over-Expression of HER-2

Plain-language summary

This study examined the spread of cancer to the brain (brain metastasis) in patients with breast cancer, with and without over-expression of HER-2. Women aged 18 and over whose breast cancer had spread to the brain and who were scheduled for surgery to remove the tumor could take part. It was carried out as a study with no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Start date

10/1/2003

Estimated completion

11/1/2004

Countries

United States

Related genes

Locations

• Bethesda, United States

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

1. A woman with a known or with radiographic evidence of a breast neoplasm metastatic to the brain.
2. Medically-indicated (diagnostic and/or therapeutic) brain tumor resection.
3. Informed consent from female patient, age 18 or older. In general, patients less than 18 years of age rarely have breast cancer metastatic to the brain.

Exclusion Criteria:

1. Inability to provide informed consent prior to surgery.
2. Medical conditions that cannot be corrected prior to surgery that would be standard contraindications for craniotomy (brain tumor patients).
3. Men.