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This study looks at the genes associated with response to the drug acamprosate in people with alcohol dependence. People aged 18 to 80 with a diagnosis of alcohol dependence under DSM-IV-TR criteria who had previously enrolled in the related DNA study could take part. This was a study without a phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: 1. Male or females, Age 18-80. 2. 2\. Primary diagnosis of alcohol dependence based on DSM-IV-TR criteria and determined by the Psychiatric Research Interview for Substance and Mental Disorders (PRISM) (stable mood and anxiety disorders will not be exclusionary). 3. Prior enrollment in the IRB approved protocol "Developing a DNA Repository for Genomic Studies of Addiction: A Pilot Study". Exclusion Criteria: 1. Inability to provide informed consent. 2. Inability to speak English. 3. History of hypersensitivity or allergic reaction to acamprosate. 4. Moderate to severe renal impairment, as determined by a creatinine level \> 1.5 mg/dL. 5. Diagnosis of primary biliary cirrhosis, chronic active hepatitis, and drug-induced hepatic insufficiency, as noted in the medical record. 6. Women who are pregnant, lactating, or are planning to become pregnant during the next year. 7. Any unstable active medical or additional psychiatric condition as determined by the investigator. 9\. Active suicidal ideation as determined by responses provided during PRISM or as determined by the investigator.