Genes, Exercise, Memory and Neurodegeneration

Plain-language summary

This study investigates the effect of aerobic exercise training, compared with stretching exercises, on memory and brain health in older adults with mild Alzheimer's disease. It enrolled people over 60 with mild Alzheimer's who were willing to exercise for 6 months. This study had no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Completed

Sponsor

Howard University

Intervention

aerobic exercise-training, stretch exercise

Start date

10/1/2009

Estimated completion

12/1/2013

Countries

United States

Related genes

Locations

• Washington D.C., United States
• Philadelphia, United States

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Age over 60 years
* Ability to exercise vigorously without harm
* Mild AD
* Study partner
* In good general health
* Willing to exercise for 6 months
* Body Mass Index (BMI) less than 37
* Women participants must be postmenopausal for at least 2 years, and maintain current hormone replacement therapy status and allowed medication usage for the duration of the study

Exclusion Criteria:

* MMSE score below 20
* TG (Triglyceride) greater than 400 mg/dl
* LDL-C levels greater than 95% or HDL-C levels less than 10% of age and sex-adjusted norms