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This study evaluates biomarkers in blood samples from older breast cancer (breast cancer) survivors using gene expression analysis and laboratory testing. It included people with a history of Stage I-III breast cancer who had undergone surgery, radiotherapy, hormonal therapy, or chemotherapy. It was carried out as a study with no assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
DISEASE CHARACTERISTICS:
* Histologically confirmed breast cancer
* Stage I-III disease
* Breast cancer survivors meeting 1 of the following criteria:
* Prior surgery with or without (±) radiotherapy (RT) (cohort 1)
* Prior surgery ± RT, followed by prior or concurrent hormonal (endocrine) therapy (cohort 2)
* Must have received or be on endocrine therapy for ≥ 3 months
* Prior surgery ± RT, followed by prior chemotherapy ± endocrine therapy (cohort 3)
* No recurrent disease
* No history of clonal bone marrow disorder (i.e., myelodysplastic or myeloproliferative disorder, acute or chronic leukemia)
PATIENT CHARACTERISTICS:
* Life expectancy \> 12 months
* Absolute lymphocyte count \> 500/μL
* No acute or active infection
* No other co-morbid illness that would impair ability to participate in the study
PRIOR CONCURRENT THERAPY:
* See Disease Characteristics
* At least 3 months since prior surgery with or without radiotherapy
* At least 3 months since prior chemotherapy (cohort 3)
* No concurrent radiotherapy, chemotherapy, or experimental therapy