Genes Influencing Iron Overload State

Plain-language summary

This study investigates genes that influence iron accumulation (iron overload) in the body in people who have had frequent blood transfusions. It included people who had received at least 12 lifetime red blood cell transfusions. It is an observational (non-phase) study and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

St. Jude Children's Research Hospital

Start date

9/21/2010

Estimated completion

4/17/2019

Countries

United States

Related genes

Locations

• Memphis, United States

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* History of ≥ 12 lifetime erythrocyte transfusions who have not yet initiated treatment to unload iron (iron chelation or therapeutic phlebotomy), or
* History of ≥ 12 lifetime erythrocyte transfusions who have initiated treatment to unload iron, but had liver iron content measurement (by R2\*MRI) within 3 months prior to initiation of iron unloading treatment

Exclusion Criteria

* Known contraindication to performance of MRI (e.g.: presence of MRI-incompatible ferromagnetic material in the body)
* Prior participation on the St. Jude MRIRON protocol