Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

Plain-language summary

This study compares breast cancer screening advice based on a personalized risk assessment with a standard approach. Participants complete a health questionnaire and provide a saliva sample for genetic testing. Women aged 30 to 74 living in the United States without a prior breast cancer diagnosis can take part. It is a trial without an assigned phase and is currently recruiting.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Recruiting

Sponsor

University of California, San Francisco

Intervention

Complete a health questionnaire, Provide a saliva sample for genetic testing, Screening advice based on a comprehensive risk assessment, Screening advice based on a basic risk assessment

Start date

8/31/2016

Estimated completion

9/1/2026

Countries

United States

Related genes

Locations

• Birmingham, United States
• Irvine, United States
• Los Angeles, United States
• Sacramento, United States
• San Diego, United States
• San Francisco, United States
• Miami, United States
• Chicago, United States
• New Orleans, United States
• New York, United States
• Sioux Falls, United States

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

1. Female\*
2. Age 30 years to 74 years old\*\*
3. Reside in the United States\*\*\*

NOTE\*: As of 2019, we are now enrolling all persons who identify as female, and will capture both their sex at birth and gender identity in the baseline survey.

NOTE\*\*: Eligibility from 2016 - October 2023 included ages 40-74 (WISDOM 1.0) and expanded to age 30 in October 2023 (WISDOM 2.0).

NOTE\*\*\*: As of 2019, recruitment is available nationwide. Original eligibility was limited to California, North Dakota, South Dakota, Iowa, Minnesota, Alabama, Louisiana, Illinois OR have coverage from a participating health plan.

Exclusion Criteria:

1. Prior Breast cancer or ductal carcinoma in situ (DCIS) diagnosis
2. Prior prophylactic bilateral mastectomy
3. Inability to provide consent
4. Non-English or Spanish proficiency (Spanish participation available: June 2019)