Targeting the Mechanisms Underlying Cutaneous Neurofibroma Formation in NF1: A Clinical Translational Approach.

Plain-language summary

This study used skin biopsies to examine the mechanisms behind the formation of cutaneous neurofibromas in people with neurofibromatosis type 1 (NF1). It included people over 18 with an established NF1 diagnosis, based on clinical criteria or genetic testing, who had cutaneous neurofibromas. It was a non-phase study and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

Corewell Health West

Intervention

Skin Biopsy

Start date

5/1/2016

Estimated completion

6/1/2025

Countries

United States

Related genes

Locations

• Grand Rapids, United States

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

1. Any subject with an established diagnosis NF1 and CNFs. The diagnosis may be based on clinical criteria or genetic testing.
2. Age \>18 years.

Exclusion Criteria:

1. Adults with diminished decision-making capacity with no defined legal guardian.
2. Prisoners.
3. Pregnant women.

3\) Breastfeeding mothers.