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This is a research network studying craniosynostosis (premature fusion of the skull bones) and related skull malformations. It collects samples such as environmental surveys, photographs, buccal swabs, blood and skin biopsies from participants. It enrolls people diagnosed with coronal craniosynostosis along with their unaffected relatives and controls. This is a study with no assigned phase; it is not currently recruiting but is still ongoing (active, not recruiting).
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Cases with diagnosis of coronal * Unaffected relatives of cases * Unaffected controls including those who may have undergone clinically indicated craniofacial surgery for trauma or conditions other than craniosynostosis or bone disease. These individuals will be recruited at some of the other collaborating institutions, but not at Mount Sinai. Individuals of any racial or ethnic group with the established or suspected clinical diagnosis of coronal, nonsyndromic craniosynostosis will be included in this study. Unaffected relatives, such as their biological parents and/or sibs, will also be included to contribute medical information and samples as negative controls for our study. Exclusion Criteria: * Those who fit the criteria, but who choose not to participate * Those who do not meet the criteria. * Other than children, no vulnerable individuals will be recruited, such as intellectual impaired individuals or prisoners.