Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso

Plain-language summary

This study examined the effects of different antibiotics (Azithromycin, Amoxicillin, Cotrimoxazole) and placebo on antibiotic resistance and the gut microbiome in children aged 6 to 59 months in the Nouna area of Burkina Faso. It enrolled children who were not currently on antibiotics and lived in a household with at least two children in this age range. It was carried out in Phase 4 and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Phase 4

Status

Completed

Sponsor

University of California, San Francisco

Intervention

Azithromycin, Amoxicillin, Cotrimoxazole, Placebo

Start date

7/4/2017

Estimated completion

9/1/2019

Countries

United States, Burkina Faso

Related genes

Locations

• San Francisco, United States
• Nouna, Burkina Faso

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Households will be eligible for inclusion in the study if they have 2 or more children aged 6 months to 59 months currently residing in the household. Children from the household will be eligible if they are 6-59 months of age and are not currently receiving antibiotic treatment

Exclusion Criteria:

* Children who are allergic to any of the study antibiotics will be excluded. Individuals aged under 6 months and 5 years or older will be excluded. Children already receiving antibiotics for an ongoing disease will be excluded.