DNA Methylation Profile of the SOCS-1 Gene Promoter in Smokers Patients With Chronic Periodontitis.

Plain-language summary

This study examined the DNA methylation profile of the SOCS-1 gene promoter region in smokers with chronic periodontitis (chronic gum inflammation). It enrolled patients with chronic periodontitis who had smoked 10 or more cigarettes a day for at least five years. The trial was a non-phase study and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

University of Sao Paulo

Intervention

oral epithelial cells obtained by rinsing with 3% sucrose

Start date

6/6/2016

Estimated completion

11/18/2017

Countries

Brazil

Related genes

Locations

• Ribeirão Preto, Brazil

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Chronic Periodontitis carriers - presence of proximal insertion loss ≥5 mm in more than 30% of the teeth present.
* Periodontal pocket ≥ 5mm
* Smokers who have smoked 10 or more cigarettes per day for the past five years.
* No positive history of basic periodontal treatment in the last six months.

Exclusion Criteria:

* Extensive prosthetic involvement.
* Using anti-inflammatories.
* Pregnant or nursing.
* Presence of systemic alterations that compromise host response or require prophylactic medication for treatment.
* History of constant use of oral antiseptics in the last six months.