This study examined the DNA methylation profile of the SOCS-1 gene promoter region in smokers with chronic periodontitis (chronic gum inflammation). It enrolled patients with chronic periodontitis who had smoked 10 or more cigarettes a day for at least five years. The trial was a non-phase study and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Chronic Periodontitis carriers - presence of proximal insertion loss ≥5 mm in more than 30% of the teeth present. * Periodontal pocket ≥ 5mm * Smokers who have smoked 10 or more cigarettes per day for the past five years. * No positive history of basic periodontal treatment in the last six months. Exclusion Criteria: * Extensive prosthetic involvement. * Using anti-inflammatories. * Pregnant or nursing. * Presence of systemic alterations that compromise host response or require prophylactic medication for treatment. * History of constant use of oral antiseptics in the last six months.