Yükleniyor... / Loading...
This is an observational study aimed at better understanding how patients with diabetes can be grouped (patient stratification). It included white European individuals aged 35-75 who either did not yet have a diagnosis of type 2 diabetes or had been diagnosed within the past 6-24 months. It was conducted as a study with no assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Study 1 Inclusion criteria * No treatment with insulin-sensitising, glucose-lowering or other antidiabetic drugs * Fasting capillary blood glucose \<10 mmol/l at baseline * White European (self-report of parental ethnicity) * Age ≥35 and \<75 years Exclusion criteria * Diagnosed diabetes of any type, HbA1c ≥6.5% (48 mmol/mol) or fasting plasma glucose ≥7.0 mmol/l or 2 h plasma glucose \>11.0 mmol/l previously * For women, pregnancy, lactation or plans to conceive within the study period * Use of a pacemaker * Any other significant medical reason for exclusion as determined by the investigator Study 2 Inclusion Criteria: * Patients diagnosed with type 2 diabetes not less than 6 months and not more than 24 months before baseline examination * Management by lifestyle with or without metformin therapy * All HbA1c \<7.6% (\<60 mmol/mol) within previous 3 months * White European * Age ≥35 and \<75 * Estimated GFR \>50 ml/min' Exclusion Criteria: * Type 1 diabetes * A previous HbA1c \>9.0% (\>75 mmol/mol) * Prior treatment with insulin or an oral hypoglycaemic agent other than metformin * BMI \<20 or \>50 kg/m2 * Pregnancy, lactation or plans to conceive within the study period * Any other significant medical reason for exclusion as determined by the investigator