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This study examines the effects of remote ischemic conditioning on hand use in individuals with spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). It included people aged 18-75 who had the relevant diagnosis and met certain muscle-function criteria, as well as able-bodied participants. It was conducted as a study with no assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Able-bodied participants 1. Age between 18 and 75 years; 2. No known central or peripheral neurological disease or injury. SCI participants Inclusion Criteria: 1. Age between 18 and 75 years; 2. Chronic (more than 12 months since injury) motor-incomplete SCI between neurological levels C2-C8 3. Detectable F-wave responses of the left or right abductor pollicis brevis (APB) to median nerve stimulation; 4. Detectable motor evoked potentials in left or right APB muscles to transcranial magnetic stimulation; 5. Able to perform thumb-middle finger opposition pinch task with detectable APB EMG muscle activity. ALS participants 1. Age between 21 and 75 years; 2. Diagnosis of probable or definite ALS. 3. Incomplete weakness of left or right wrist or hand muscles: score of 2, 3, or 4 (out of 5) on manual muscle testing of finger extension, finger flexion, or finger abduction. 4. Detectable motor evoked potentials in left or right APB muscles to transcranial magnetic stimulation; 5. Able to perform thumb-middle finger opposition pinch task with detectable APB electromyography (EMG) muscle activity. Exclusion Criteria: 1. Multiple spinal cord lesions; 2. History of seizures; 3. Use of medications that significantly lower seizure threshold, such as amphetamines and bupropion; 4. History of implanted brain/spine/nerve stimulators, aneurysm clips, or cardiac pacemaker/defibrillator; 5. Any extremity soft tissue, orthopedic, or vascular condition or injury that may contraindicate remote limb ischemic conditioning (RLIC) (uncontrolled hypertension, peripheral vascular disease, hematological disease, severe hepatic or renal dysfunction); 6. Any other contraindication to undergoing magnetic resonance imaging (except for claustrophobia); 7. Clinically significant infection of any kind (urinary tract, pulmonary, skin or other) 8. Significant coronary artery or cardiac conduction disease; 9. Open skin lesions over the neck, shoulders, or arms; 10. Pregnancy 11. Unsuitable for study participation as determined by study physician. In addition, a medical record review will be conducted to identify any other medical concerns that might increase the risks associated with participation.