Effect of Saturated Fat (Desi Ghee) on Gut-Liver Axis in Alcoholic Hepatitis

Plain-language summary

This study compares the effect of a saturated fat (Desi Ghee, clarified butter) versus soybean oil on the gut-liver axis in patients with alcoholic hepatitis. Patients aged 18-60 with severe alcoholic hepatitis and a Maddrey score above 32 were included. It was carried out as a study with no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Completed

Sponsor

Institute of Liver and Biliary Sciences, India

Intervention

Saturated Fat- Desi Ghee (Clarified Butter), Soyabean Oil

Start date

10/1/2019

Estimated completion

1/31/2022

Countries

India

Related genes

Locations

• New Delhi, India

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

All patients with Severe Alcoholic Hepatitis

* Aged between 18-60 years
* Having Maddrey Score of \>32
* Last Intake of alcohol from 1 day to 60days
* Patients who agree for complete alcohol abstinence from the day of enrollment

Exclusion Criteria:

Patients with-

* Maddrey Score of \<32 and \>100
* Comorbidities- Diabetes, Hypertension, Coronary Artery Disease, Chronic Kidney Disease, Hypothyroid
* Continuing Alcohol intake- Non-compliant patients
* Constipation
* On Laxatives until 1 month prior to study
* On probiotics until 1 month prior to study