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This study examined the effects of a personalized home-based training program combining endurance and muscle-strengthening exercises in patients with Marfan syndrome. It enrolled patients diagnosed with Marfan syndrome according to the Ghent criteria who were receiving aorta-protective treatment. This is a study without an assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * patient with Marfan syndrome and followed up at Bichat Claude Bernard hospital, Paris. Marfan syndrome should be diagnosed according to the Ghent nosology revised in 2010 * Patient taking protective treatment for the aorta (beta blocker, calcium channel blocker, ACE inhibitor, angiotensin II receptor antagonist). * Valid patient, able to return to consultation and carry out functional assessments and personalized physical training at home. * Patients operated prophylactically on the ascending aorta may be included at a distance \> 6 months from their surgery. Exclusion Criteria: * Myocardial pathology other than Marfan syndrome. * Thoracic aorta dissection. * Aortic diameter \> 45 millimeters. * Uncontrolled high blood pressure at rest (systolic blood pressure \> 140 Millimeter of mercury and diastolic blood pressure \> 90 Millimeter of mercury) * Increase in systolic blood pressure \> 160 Millimeter of mercury during exercise. * Pregnancy at the time of the study