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This study investigates possible genetic subgroups in fibromyalgia patients by examining pain responses with an electrophysiological measurement called the nociceptive flexion reflex (RIII reflex). It enrolled patients aged 18-65 diagnosed with fibromyalgia by the 2016 ACR criteria, along with pain-free volunteers for comparison. The study was conducted as a non-phase study and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Patient Inclusion criteria : * Patient between 18 and 65 years old (included), * Patient with fibromyalgia according to the criteria of the 2016 ACR, * Patient weighing more than 45kg * Cooperation and understanding sufficient to comply with the requirements of the study, * Acceptance to give written consent, * Affiliation to the French Social Security system, Patient exclusion criteria : * treated with antibiotics in the three months prior to inclusion, * who has reported gastroenteritis in the two months prior to inclusion, * having a medical and / or surgical history judged by the investigator or his representative to be incompatible with the test * of childbearing age not using an effective contraceptive method, pregnant or breastfeeding woman. * participating in another clinical trial, or being in the exclusion period, or having received a total amount of benefits exceeding EUR 4500 over the 12 months preceding the start of the trial, * benefiting from a measure of legal protection (guardianship, guardianship, deprivation of liberty, safeguard of justice), Subject inclusion criteria: * Aged of more than 18 years, * weighing more than 45kg * non-painful subjects matched by age (+/- 5 years), by sex, and by menopausal status for women, * Cooperation and understanding sufficient to comply with the requirements of the study, * Acceptance of written consent, * Affiliation to the French Social Security system, * Registration or acceptance of registration in the National Register of Volunteers participating in research. Subject exclusion criteria : * treated with antibiotics in the three months prior to inclusion, * who has reported gastroenteritis in the two months prior to inclusion, * Medical and / or surgical history judged by the investigator or his representative to be incompatible with the test, * Intake of any drugs in the 7 days before inclusion, * Pregnant or nursing woman * Participating in another clinical trial, or within the exclusion period, or having received a total amount of compensation in excess of EUR 4500 over the 12 months preceding the start of the trial, * Benefiting from a measure of legal protection (curatorship, guardianship, safeguard of justice ...)